Photochemicallly Induced Thrombosis as a Model of Ischemic Stroke

Better understanding of ischemic brain injury mechanisms is important for the development and improvement diagnostic therapeutic modalities management stroke. As experimental studies are on demand, there’s a need relevant models focal lesions. Photochemically induced thrombosis remains one most popular The purpose review to consider pathogenesis applicational relevance photochemical in stroke modeling. Material methods. information was searched using PubMed Google Scholar databases keywords «photothrombotic stroke» without language restrictions. 74 papers out more than 600 sources were found this selected analysis. Of these, 50% have been published last five years. criterion excluding source an inconsistency with objectives low content. Results. We outlined variety features modeling photothrombotic stroke, analyzed advantages disadvantages model, presented data current method’s modifications, as well approaches evaluation lesions by photothrombosis, summarized about damage model. Conclusion. Several such invasiveness, high reproducibility, inherent control infarction volume mortality, determine its active use Pathological processes modeled similar occurring acute cerebral circulation events. Therefore, model provides insights into cellular molecular damage, can be used developing novel